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IM or IV Substitution For Oral Phenytoin Therapy Cerebyx can be substituted for oral phenytoin sodium therapy at the same total daily dose. Dilantin capsules are approximately 90% bioavailable by the oral route. Phenytoin, supplied as Cerebyx, is 100% bioavailable by both the IM and IV routes.Phenytoin is often used to control status epilepticus, but its water-soluble prodrug, fosphenytoin, may be more useful as it is easier to administer. We studied the pharmacokinetics and clinical effects of phenytoin and fosphenytoin sodium in children with severe falciparum malaria and status epilepticus.Other commonly used medications such as omeprazole ( Prilosec), phenytoin ( Dilantin), and isoniazid (INH) may increase the risk of liver injury caused by acetaminophen. It is always in the liver patient's best interests to consult with his or her hepatologist prior to taking any medication.Fosphenytoin (Cerebyx) is a more water-soluble prodrug form of phenytoin that allows for faster IV infusion and less risk of extravasation injury. Because its molecular weight is different than that of phenytoin, one milligram of fosphenytoin does not equal one milligram of phenytoin.Fosphenytoin (fosphenytoin sodium, trade names Cerebyx, Parke-Davis; Prodilantin, Pfizer Holding France) is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. It is most commonly used in the acute treatment http://canadapharmaceutics.com female viagra order online of convulsive status epilepticus.That is one of the reasons why there is preference for fosphenytoin which is a pro-drug from of dilantin and is more soluble in saline. I have always given Dilantin by IV push, even the large November 10, 2007 | order viagra pills iv-therapy.net I have always given Dilantin by IV push, Mar 26, 2010One cause seems to lie in the narrow therapeutic range of some drugs, the difference in dosage between that which is less than effective and that …There is a similar formulation called fosphenytoin, which is similarly soluble in water as phenytoin sodium but much safer for IV administration -- phenytoin can be very irritating, whereas fosphenytoin is less so -- and it is dosed in phenytoin equivalents.Because phenytoin is highly protein bound and only unbound drug is capable of crossing the blood-brain barrier to exert its pharmacologic effect, unbound (free) phenytoin levels may be more clinically relevant than total levels to maximize efficacy and minimize toxicity. 3, 4

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